Allosteric modulation of [(3)H]gabapentin binding by ruthenium red.

@article{Taylor2000AllostericMO,
  title={Allosteric modulation of [(3)H]gabapentin binding by ruthenium red.},
  author={Miriam T Taylor and D. W. Bonhaus},
  journal={Neuropharmacology},
  year={2000},
  volume={39 7},
  pages={1267-73}
}
Gabapentin is an anticonvulsant with an unknown mechanism of action. However, it has been proposed that gabapentin acts by binding to voltage-gated calcium channels. To further characterize the interaction of gabapentin with its endogenous binding site in cerebral cortex, we tested for competitive and allosteric interactions between [(3)H]gabapentin and a variety of calcium channel binding ligands. Most ligands for voltage- or ligand-gated calcium channels (verapamil, the omega-conotoxins MVIIC… CONTINUE READING