Allosteric mechanisms can be distinguished using structural mass spectrometry.

  title={Allosteric mechanisms can be distinguished using structural mass spectrometry.},
  author={A. Dyachenko and Ranit Gruber and Liat Shimon and Amnon Horovitz and Michal Sharon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 18},
The activity of many proteins, including metabolic enzymes, molecular machines, and ion channels, is often regulated by conformational changes that are induced or stabilized by ligand binding. In cases of multimeric proteins, such allosteric regulation has often been described by the concerted Monod-Wyman-Changeux and sequential Koshland-Némethy-Filmer classic models of cooperativity. Despite the important functional implications of the mechanism of cooperativity, it has been impossible in many… CONTINUE READING
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