Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels.

@article{Cui2000AllostericLB,
  title={Allosteric linkage between voltage and Ca(2+)-dependent activation of BK-type mslo1 K(+) channels.},
  author={Jianmin Cui and Richard W. Aldrich},
  journal={Biochemistry},
  year={2000},
  volume={39 50},
  pages={15612-9}
}
The activation of BK type Ca(2+)-activated K(+) channels depends on both voltage and Ca(2+). We studied three point mutations in the putative voltage sensor S4 or S4-S5 linker regions in the mslo1 BK channels to explore the relationship between voltage and Ca(2+) in activating the channel. These mutations reduced the steepness of the open probability - voltage (P(o) - V) relation and increased the shift of the P(o) - V relations on the voltage axis in response to increases in the calcium… CONTINUE READING
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Allosteric Activation of mslo1 Channels Biochemistry, Vol

  • D. Sigg, F. Bezanilla
  • J. Gen. Physiol. 109,
  • 1997

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