Allosteric kinetics of the isoform 1 of human glucosamine-6-phosphate deaminase.

Abstract

The human genome contains two genes encoding for two isoforms of the enzyme glucosamine-6-phosphate deaminase (GNPDA, EC 3.5.99.6). Isoform 1 has been purified from several animal sources and the crystallographic structure of the human recombinant enzyme was solved at 1.75Å resolution (PDB ID: 1NE7). In spite of their great structural similarity, human and… (More)
DOI: 10.1016/j.bbapap.2011.07.010

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