Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors.

@article{Bonhaus1995AllostericIA,
  title={Allosteric interactions among agonists and antagonists at 5-hydroxytryptamine3 receptors.},
  author={D. W. Bonhaus and Eric G. Stefanich and D N Loury and S. A. O. Hsu and R. M. Eglen and Erik H. F. Wong},
  journal={Journal of neurochemistry},
  year={1995},
  volume={65 1},
  pages={104-10}
}
Cooperation in the action of agonists suggests that there are multiple binding sites on 5-hydroxytryptamine3 (5-HT3) receptors. The purpose of this study was to characterize these binding sites and their interactions on both native and cloned 5-HT3 receptors. The affinities of competitive 5-HT3 receptor antagonists were similar regardless of whether the receptors were labeled with [3H]RS-42358, [3H]granisetron, or 1-(m-[3H]chlorophenyl)biguanide ([3H]mCPG). By contrast, the affinities of the… CONTINUE READING

From This Paper

Topics from this paper.
4 Citations
0 References
Similar Papers