Allosteric inhibitors of plasma membrane Ca pumps: Invention and applications of caloxins.

@article{Pande2011AllostericIO,
  title={Allosteric inhibitors of plasma membrane Ca pumps: Invention and applications of caloxins.},
  author={Jyoti Pande and Magdalena M. Szewczyk and A. K. Grover},
  journal={World journal of biological chemistry},
  year={2011},
  volume={2 3},
  pages={39-47}
}
Plasma membrane Ca(2+) pumps (PMCA) play a major role in Ca(2+) homeostasis and signaling by extruding cellular Ca(2+) with high affinity. PMCA isoforms are encoded by four genes which are expressed differentially in various cell types in normal and disease states. Therefore, PMCA isoform selective inhibitors would aid in delineating their role in physiology and pathophysiology. We are testing the hypothesis that extracellular domains of PMCA can be used as allosteric targets to obtain a novel… CONTINUE READING