Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

  title={Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.},
  author={Yoonsang Cho and Gregg V. Crichlow and Jon J. Vermeire and Lin Leng and Xin Du and Michael E. Hodsdon and Richard Bucala and Michael Cappello and Matt Gross and Federico C. A. Gaeta and Kirk W. Johnson and Elias J Lolis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={107 25},
AV411 (ibudilast; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a]pyridine) is an antiinflammatory drug that was initially developed for the treatment of bronchial asthma but which also has been used for cerebrovascular and ocular indications. It is a nonselective inhibitor of various phosphodiesterases (PDEs) and has varied antiinflammatory activity. More recently, AV411 has been studied as a possible therapeutic for the treatment of neuropathic pain and opioid withdrawal through its actions on glial… CONTINUE READING
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