Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

@article{BarryHamilton2010AllostericIO,
  title={Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment},
  author={Vivian Barry-Hamilton and Rhyannon Spangler and Derek C. Marshall and Scott McCauley and Hector M. Rodriguez and Miho Oyasu and Amanda J Mikels and Maria Vaysberg and Haben Ghermazien and Carol Wai and Carlos A. Cuello Garcia and Arleene C. Velayo and Brett Jorgensen and Donna H T Biermann and Daniel Tsai and Jennifer Green and Shelly Zaffryar-Eilot and Alison K. Holzer and Scott Ogg and Dung Thai and Gera Neufeld and Peter Van Vlasselaer and Victoria B. Smith},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={1009-1017}
}
We have identified a new role for the matrix enzyme lysyl oxidase–like-2 (LOXL2) in the creation and maintenance of the pathologic microenvironment of cancer and fibrotic disease. Our analysis of biopsies from human tumors and fibrotic lung and liver tissues revealed an increase in LOXL2 in disease-associated stroma and limited expression in healthy tissues. Targeting LOXL2 with an inhibitory monoclonal antibody (AB0023) was efficacious in both primary and metastatic xenograft models of cancer… CONTINUE READING
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