Allosteric inhibition of kinesin-5 modulates its processive directional motility.

  title={Allosteric inhibition of kinesin-5 modulates its processive directional motility.},
  author={Benjamin H. Kwok and Lukas C Kapitein and Jeffrey H. Kim and Erwin J. G. Peterman and Christoph F Schmidt and Tarun M Kapoor},
  journal={Nature chemical biology},
  volume={2 9},
Small-molecule inhibitors of kinesin-5 (refs. 1-3), a protein essential for eukaryotic cell division, represent alternatives to antimitotic agents that target tubulin. While tubulin is needed for multiple intracellular processes, the known functions of kinesin-5 are limited to dividing cells, making it likely that kinesin-5 inhibitors would have fewer side effects than do tubulin-targeting drugs. Kinesin-5 inhibitors, such as monastrol, act through poorly understood allosteric mechanisms, not… CONTINUE READING

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