Allosteric gating of Son of sevenless activity by the histone domain.


Regulated activation of Ras by receptor tyrosine kinases (RTK) constitutes a key transduction step in signaling processes that control an array of fundamental cellular functions including proliferation, differentiation, and survival. The principle mechanism by which Ras is activated down stream of RTKs involves the stimulation of guanine nucleotide exchange… (More)
DOI: 10.1073/pnas.0914315107


4 Figures and Tables