Allosteric effects of DNA on transcriptional regulators

@article{Lefstin1998AllostericEO,
  title={Allosteric effects of DNA on transcriptional regulators},
  author={Jeffrey A. Lefstin and Keith R. Yamamoto},
  journal={Nature},
  year={1998},
  volume={392},
  pages={885-888}
}
Selective gene transcription is mediated in part by regulatory proteins that bind to DNA response elements. These regulatory proteins receive global information from signal-transduction events. But transcriptional regulators may also be modified in an allosteric manner by response elements themselves to generate the pattern of regulation that is appropriate to an individual gene. 

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