Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding.

Abstract

Peptide sequences modified with lanthanide-chelating groups at their N-termini, or at their lysine side chains, were synthesized, and new Ln(III) complexes were characterized. We show that partial folding of the conjugates to form trimer coiled coil structures induces coordination of lanthanides to the ligand, which in turn further stabilizes the 3D structure.

DOI: 10.1039/c2cc35166h

Cite this paper

@article{Samiappan2012AllostericEI, title={Allosteric effects in coiled-coil proteins folding and lanthanide-ion binding.}, author={Manickasundaram Samiappan and Samaa Alasibi and Rivka Cohen-Luria and Abraham Shanzer and Gonen Ashkenasy}, journal={Chemical communications}, year={2012}, volume={48 77}, pages={9577-9} }