Allosteric coupling between morphine and enkephalin receptors in vitro.

@article{Rothman1982AllostericCB,
  title={Allosteric coupling between morphine and enkephalin receptors in vitro.},
  author={Richard B. Rothman and Thomas C. Westfall},
  journal={Molecular pharmacology},
  year={1982},
  volume={21 3},
  pages={548-57}
}
In a recent paper from our laboratory [Mol. Pharmacol 21:538-547 (1982)] evidence was presented which suggested that [3H]leucine enkephalin labels a single class of binding sites (the enkephalin receptor) and that morphine allosterically induces a masking of enkephalin receptors as a consequence of binding to a receptor (the morphine receptor) not labeled by the 3H-peptide. Evidence is presented in this paper that [3H]etorphine can be used to label selectively the morphine receptor and that the… CONTINUE READING