Allosteric cooperativity in protein kinase A.

  title={Allosteric cooperativity in protein kinase A.},
  author={Larry R. Masterson and Alessandro Mascioni and Nathaniel J Traaseth and Susan S. Taylor and Gianluigi Veglia},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 2},
Allosteric signaling in proteins requires long-range communication mediated by highly conserved residues, often triggered by ligand binding. In this article, we map the allosteric network in the catalytic subunit of protein kinase A using NMR spectroscopy. We show that positive allosteric cooperativity is generated by nucleotide and substrate binding during… CONTINUE READING