Allosteric conversion of Z DNA to an intercalated right-handed conformation by daunomycin.

@article{Chaires1986AllostericCO,
  title={Allosteric conversion of Z DNA to an intercalated right-handed conformation by daunomycin.},
  author={Jonathan B. Chaires},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 19},
  pages={
          8899-907
        }
}
Absorbance and fluorescence methods were used to measure the binding of the anticancer drug daunomycin to poly (dGdC) under ionic conditions that initially favor the left-handed Z conformation of the polymer. Drug binding was cooperative under these conditions and may be fully accounted for by an allosteric model in which the drug binds preferentially (but not exclusively) to the right-handed B conformation and shifts the polymer from the Z to an intercalated right-handed conformation… CONTINUE READING