Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation

  title={Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation},
  author={Yang Han and Irina S. Moreira and Eneko Urizar and Harel Weinstein and Jonathan A. Javitch},
  booktitle={Nature chemical biology},
A major obstacle to understanding the functional importance of dimerization between class A G protein-coupled receptors (GPCRs) has been the methodological limitation in achieving control of the identity of the components comprising the signaling unit. We have developed a functional complementation assay that enables such control, and we demonstrate it here for the human dopamine D2 receptor. The minimal signaling unit, two receptors and a single G protein, is maximally activated by agonist… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.
Showing 1-10 of 131 extracted citations

Identification and characterization of Adenosine A 2 A heteromers in the CNS

Marc Brugarolas Campillos sota la direcció del Dr. Rafa Burillo
View 6 Excerpts
Highly Influenced

G Protein-Coupled Receptors - Modeling and Simulation

Advances in Experimental Medicine and Biology • 2014
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 69 references

Crystal structure of opsin in its Gproteininteracting conformation

P. Scheerer
Nature • 2008

Dopamine D2 receptors form higher order oligomers at physiological expression levels

W Guo
EMBO J • 2008

Activation of a Dimeric Metabotropic Glutamate Receptor by Intersubunit Rearrangement

C Brock
J. Biol. Chem 2007;282:33000–33008 • 2007
View 2 Excerpts

Similar Papers

Loading similar papers…