Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation

@inproceedings{Han2009AllostericCB,
  title={Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation},
  author={Yang Han and Irina S. Moreira and Eneko Urizar and Harel Weinstein and Jonathan A. Javitch},
  booktitle={Nature chemical biology},
  year={2009}
}
A major obstacle to understanding the functional importance of dimerization between class A G protein-coupled receptors (GPCRs) has been the methodological limitation in achieving control of the identity of the components comprising the signaling unit. We have developed a functional complementation assay that enables such control, and we demonstrate it here for the human dopamine D2 receptor. The minimal signaling unit, two receptors and a single G protein, is maximally activated by agonist… CONTINUE READING
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