Allosteric activation of latent p53 tetramers.

  title={Allosteric activation of latent p53 tetramers.},
  author={Ted R. Hupp and D. P. Lane},
  journal={Current biology : CB},
  volume={4 10},
BACKGROUND The DNA-binding activity of p53 is essential to its function as a tumour suppressor. Point mutations that abolish this activity have been found to occur frequently in the p53 genes of human cancer cells. Wild-type p53 protein assembles into oligomers with latent DNA-binding activity that can be activated in vitro by phosphorylation of a carboxy-terminal regulatory region, catalyzed by protein kinase C or casein kinase II. We have investigated the mechanism underlying this post… CONTINUE READING
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