Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction.

Abstract

In many bacterial pathogens, the second messenger c-di-GMP stimulates the production of an exopolysaccharide (EPS) matrix to shield bacteria from assaults of the immune system. How c-di-GMP induces EPS biogenesis is largely unknown. Here, we show that c-di-GMP allosterically activates the synthesis of poly-β-1,6-N-acetylglucosamine (poly-GlcNAc), a major… (More)
DOI: 10.1038/emboj.2012.315

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Cite this paper

@article{Steiner2013AllostericAO, title={Allosteric activation of exopolysaccharide synthesis through cyclic di-GMP-stimulated protein-protein interaction.}, author={Samuel Steiner and Christian Lori and Alexander Boehm and Urs Jenal}, journal={The EMBO journal}, year={2013}, volume={32 3}, pages={354-68} }