Allosteric Voltage Gating of Potassium Channels II mSlo Channel Gating Charge Movement in the Absence of Ca 2

@inproceedings{Horrigan1999AllostericVG,
  title={Allosteric Voltage Gating of Potassium Channels II mSlo Channel Gating Charge Movement in the Absence of Ca 2},
  author={Frank T. Horrigan and Richard W. Aldrich},
  year={1999}
}
Large-conductance Ca 2 1 -activated K 1 channels can be activated by membrane voltage in the absence of Ca 2 1 binding, indicating that these channels contain an intrinsic voltage sensor. The properties of this voltage sensor and its relationship to channel activation were examined by studying gating charge movement from mSlo Ca 2 1 -activated K 1 channels in the virtual absence of Ca 2 1 ( , 1 nM). Charge movement was measured in response to voltage steps or sinusoidal voltage commands. The… CONTINUE READING