Allosteric Regulation in Gating the Central Channel of the Nuclear Pore Complex

@article{Koh2015AllostericRI,
  title={Allosteric Regulation in Gating the Central Channel of the Nuclear Pore Complex},
  author={Junseock Koh and G{\"u}nter Blobel},
  journal={Cell},
  year={2015},
  volume={161},
  pages={1361-1373}
}
  • Junseock Koh, Günter Blobel
  • Published in Cell 2015
  • Medicine, Biology
  • The nuclear pore complex (NPC) arose in evolution as the cell's largest and most versatile transport channel. Current models for selective transport mediated by NPCs are focused on properties of intrinsically disordered regions of nucleoporins that bind transport factors. In contrast, structured regions are considered to provide static anchoring sites for the disordered regions without affecting transport factor binding. Here, we demonstrate allosteric coupling between a structured domain of a… CONTINUE READING

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