Allosteric Na+-binding site modulates CXCR4 activation.

@article{Cong2018AllostericNS,
  title={Allosteric Na+-binding site modulates CXCR4 activation.},
  author={Xiaojing Cong and J{\'e}r{\^o}me Golebiowski},
  journal={Physical chemistry chemical physics : PCCP},
  year={2018},
  volume={20 38},
  pages={
          24915-24920
        }
}
G protein-coupled receptors (GPCRs) control most cellular communications with the environment and are the largest protein family of drug targets. As strictly regulated molecular machines, profound comprehension of their activation mechanism is expected to significantly facilitate structure-based drug design. This study provides atomistic-level description of the activation dynamics of the C-X-C chemokine receptor type 4 (CXCR4), a class A GPCR and important drug target. Using molecular dynamics… 
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