Allosteric Modulation of the Cannabinoid CB1 Receptor

@article{Price2005AllostericMO,
  title={Allosteric Modulation of the Cannabinoid CB1 Receptor},
  author={Martin R Price and G. Baillie and A. Thomas and L. Stevenson and M. Easson and R. Goodwin and Ad{\`e}le McLean and L. McIntosh and G. Goodwin and G. Walker and P. Westwood and Julia Marrs and F. Thomson and P. Cowley and A. Christopoulos and R. Pertwee and R. Ross},
  journal={Molecular Pharmacology},
  year={2005},
  volume={68},
  pages={1484 - 1495}
}
We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-fluoro-1H-indole-2-carboxylic acid [2-94-dimethylamino-phenyl)-ethyl]-amide), and Org 29647 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid (1-benzyl-pyrrolidin-3-yl)-amide, 2-enedioic acid salt), at the cannabinoid CB1 receptor. In equilibrium binding assays, the Org compounds significantly increased the binding of the… Expand
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