Allosteric Modulation of Retinal GABA Receptors by Ascorbic Acid

@article{Calero2011AllostericMO,
  title={Allosteric Modulation of Retinal GABA Receptors by Ascorbic Acid},
  author={Cecilia I Calero and Evan D. Vickers and Gustavo Moraga Cid and L. Aguayo and H. von Gersdorff and D. Calvo},
  journal={The Journal of Neuroscience},
  year={2011},
  volume={31},
  pages={9672 - 9682}
}
Ionotropic GABA receptors (GABAA and GABAC) belong to the Cys-loop receptor family of ligand-gated ion channels. GABAC receptors are highly expressed in the retina, mainly localized at the axon terminals of bipolar cells. Ascorbic acid, an endogenous redox agent, modulates the function of diverse proteins, and basal levels of ascorbic acid in the retina are very high. However, the effect of ascorbic acid on retinal GABA receptors has not been studied. Here we show that the function of GABAC and… Expand
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