Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces Long-Term Potentiation in the Hippocampus and Enhances Cognition

  title={Allosteric Modulation of Related Ligand-Gated Ion Channels Synergistically Induces Long-Term Potentiation in the Hippocampus and Enhances Cognition},
  author={Timothy B C Johnstone and Zhenglin Gu and Ryan F. Yoshimura and Anne-Sophie Vill{\'e}gier and Derk J. Hogenkamp and Edward R. Whittemore and Jin-Cheng Huang and Minhtam B. Tran and James D. Belluzzi and Jerrel L Yakel and Kelvin W. Gee},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={908 - 915}
α5 Subunit-containing GABAA receptors (GABAARs) and α7 neuronal nicotinic-acetylcholine receptors (nAChRs) are members of the Cys-loop family of ligand-gated ion channels (LGICs) that mediate cognitive and attentional processes in the hippocampus. α5 GABAARs alter network activity by tonic inhibition of CA1/CA3 pyramidal cells of the hippocampus. Postsynaptic α7 nAChRs in the hippocampus regulate inhibitory GABAergic interneuron activity required for synchronization of pyramidal neurons in the… 

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