Allosteric Modulation of Muscarinic Acetylcholine Receptors

  title={Allosteric Modulation of Muscarinic Acetylcholine Receptors},
  author={Karen J. Gregory and Patrick M. Sexton and Arthur Christopoulos},
  journal={Current Neuropharmacology},
  pages={157 - 167}
Muscarinic acetylcholine receptors (mAChRs) are prototypical Family A G protein coupled-receptors. The five mAChR subtypes are widespread throughout the periphery and the central nervous system and, accordingly, are widely involved in a variety of both physiological and pathophysiological processes. There currently remains an unmet need for better therapeutic agents that can selectively target a given mAChR subtype to the relative exclusion of others. The main reason for the lack of such… CONTINUE READING


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