Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive Inhibitors.

@article{Lombard2018AllostericMO,
  title={Allosteric Modulation of JNK Docking Site Interactions with ATP-Competitive Inhibitors.},
  author={Chloe K. Lombard and Audrey L Davis and Takayuki Inukai and Dustin J Maly},
  journal={Biochemistry},
  year={2018},
  volume={57 40},
  pages={
          5897-5909
        }
}
The c-Jun N-terminal kinases (JNKs) play a wide variety of roles in cellular signaling processes, dictating important, and even divergent, cellular fates. These essential kinases possess docking surfaces distal to their active sites that interact with diverse binding partners, including upstream activators, downstream substrates, and protein scaffolds. Prior studies have suggested that the interactions of certain protein-binding partners with one such JNK docking surface, termed the D… Expand
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References

Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases.
TLDR
A series of inhibitors that are highly selective for the ATP-binding sites of the Src-family kinases Lyn and Hck are described, and it is shown that sensitivity to this class of selective inhibitors is due to the identity of residues that control the conformational flexibility of helix αC rather than any specific ATP- binding site interactions. Expand