Allosteric Mechanisms of Signal Transduction
@article{Changeux2005AllostericMO, title={Allosteric Mechanisms of Signal Transduction}, author={J. Changeux and S. Edelstein}, journal={Science}, year={2005}, volume={308}, pages={1424 - 1428} }
Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation.
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References
SHOWING 1-10 OF 61 REFERENCES
Allosteric proteins and cellular control systems.
- Biology, Medicine
- Journal of molecular biology
- 1963
- 1,462
- PDF
On the cooperativity of biological membranes.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1967
- 351
- PDF
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.
- Chemistry, Medicine
- Trends in pharmacological sciences
- 1993
- 779
Conformational spread: the propagation of allosteric states in large multiprotein complexes.
- Chemistry, Medicine
- Annual review of biophysics and biomolecular structure
- 2004
- 137
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
- Biology, Medicine
- Molecular Pharmacology
- 2004
- 457
- PDF
New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2004
- 89
- PDF
Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis
- Biology, Medicine
- Nature Cell Biology
- 2000
- 189
- PDF