Allosteric Mechanisms of Signal Transduction

  title={Allosteric Mechanisms of Signal Transduction},
  author={J. Changeux and S. Edelstein},
  pages={1424 - 1428}
  • J. Changeux, S. Edelstein
  • Published 2005
  • Chemistry, Medicine
  • Science
  • Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation. 
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