Allosteric Mechanisms of Signal Transduction

@article{Changeux2005AllostericMO,
  title={Allosteric Mechanisms of Signal Transduction},
  author={J. Changeux and S. Edelstein},
  journal={Science},
  year={2005},
  volume={308},
  pages={1424 - 1428}
}
  • J. Changeux, S. Edelstein
  • Published 2005
  • Chemistry, Medicine
  • Science
  • Forty years ago, a simple model of allosteric mechanisms (indirect interactions between distinct sites), used initially to explain feedback-inhibited enzymes, was presented by Monod, Wyman, and Changeux. We review the MWC theory and its applications for the understanding of signal transduction in biology, and also identify remaining issues that deserve theoretical and experimental substantiation. 
    584 Citations

    Topics from this paper.

    The structural basis of allosteric regulation in proteins
    • 149
    • PDF
    Allosteric mechanisms can be distinguished using structural mass spectrometry
    • 92
    • PDF
    Allosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock Model*
    • 61
    • PDF
    Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation
    • 47
    • PDF
    Allosteric modulation as a unifying mechanism for receptor function and regulation
    • 92
    Allosteric regulation of pentameric ligand-gated ion channels
    • 20
    Monod–Wyman–Changeux allosteric mechanisms of action and the pharmacology of etomidate
    • 29

    References

    SHOWING 1-10 OF 62 REFERENCES
    Allosteric proteins and cellular control systems.
    • 1,450
    • PDF
    Allosteric Receptors after 30 Years
    • 407
    On the cooperativity of biological membranes.
    • 349
    • PDF
    Extensions of the Allosteric Model for Haemoglobin
    • 125
    Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins.
    • 771
    Conformational spread: the propagation of allosteric states in large multiprotein complexes.
    • D. Bray, T. Duke
    • Medicine, Biology
    • Annual review of biophysics and biomolecular structure
    • 2004
    • 134
    G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
    • 456
    • PDF
    New insights into allosteric mechanisms from trapping unstable protein conformations in silica gels.
    • 89
    • PDF