Allosteric Mechanisms in Chaperonin Machines.


Chaperonins are nanomachines that facilitate protein folding by undergoing energy (ATP)-dependent movements that are coordinated in time and space owing to complex allosteric regulation. They consist of two back-to-back stacked oligomeric rings with a cavity at each end where protein substrate folding can take place. Here, we focus on the GroEL/GroES… (More)
DOI: 10.1021/acs.chemrev.5b00556


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