Allosteric Inhibition of Rat Liver Fructose 1,6-diphosphatase by Adenosine 5'-monophosphate.

This enzymatic step is presumed to be obligatory for glyconeogenesis in order to bypass the highly exergonic phosphofructokinase reaction (7). A sensitive mechanism for the regulation of fructose 1,6-diphosphatase activity would be of importance in control of the direction of flow of carbohydrate metabolism in these organs, i.e. catabolism via glycolysis or… CONTINUE READING