Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase

Abstract

A fundamental goal in cellular signaling is to understand allosteric communication, the process by which signals originated at one site in a protein propagate dependably to affect remote functional sites. Here, we describe the allosteric regulation of the receptor tyrosine kinase KIT. Our analysis evidenced that communication routes established between the… (More)
DOI: 10.1371/journal.pcbi.1002661

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Cite this paper

@inproceedings{Laine2012AllostericCA, title={Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase}, author={Elodie Laine and Christian Auclair and Luba Tchertanov}, booktitle={PLoS Computational Biology}, year={2012} }