Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins

@article{Daily2009AllostericCO,
  title={Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins},
  author={Michael D. Daily and Jeffrey J. Gray},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={88 - 118}
}
Allosteric proteins bind an effector molecule at one site resulting in a functional change at a second site. We hypothesize that allosteric communication in proteins relies upon networks of quaternary (collective, rigid-body) and tertiary (residue-residue contact) motions. We argue that cyclic topology of these networks is necessary for allosteric communication. An automated algorithm identifies rigid bodies from the displacement between the inactive and the active structures and constructs… CONTINUE READING