Allosteric Antagonism of Insect Odorant Receptor Ion Channels

@inproceedings{Jones2012AllostericAO,
  title={Allosteric Antagonism of Insect Odorant Receptor Ion Channels},
  author={Patrick L. Jones and Gregory M. Pask and Ian M. Romaine and Robert W Taylor and Paul R. Reid and Alex G. Waterson and Gary A Sulikowski and Laurence J. Zwiebel},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND At a molecular level, insects utilize members of several highly divergent and unrelated families of cell-surface chemosensory receptors for detection of volatile odorants. Most odors are detected via a family of odorant receptors (ORs), which form heteromeric complexes consisting of a well-conserved OR co-receptor (Orco) ion channel and a non-conserved tuning OR that provides coding specificity to each complex. Orco functions as a non-selective cation channel and is expressed in the… CONTINUE READING

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