Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation.

@article{Ubiali2007AllorecognitionOH,
  title={Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation.},
  author={Federica Ubiali and Sara Nava and Valeria Nessi and Simona Frigerio and Eugenio Agostino Parati and Pia Bernasconi and Renato Mantegazza and Fulvio Baggi},
  journal={International immunology},
  year={2007},
  volume={19 9},
  pages={
          1063-74
        }
}
Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immunogenicity of a human NSC line grown in normal culture conditions and in the presence of pro-inflammatory cytokines IFN-gamma and tumor necrosis factor alpha by one-way mixed… 
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The immunogenicity and post-transplantation immunological dynamics of iPSC-NSPCs resemble those of fetus-N SPCs.
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It is demonstrated that NSCs are susceptible to murine CMV infection and inflammatory mediators, such as IFN-γ, alter cellular characteristics which may have an impact on their reparative functions.
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