Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.

@article{Hirose2015AllorecognitionVT,
  title={Allorecognition, via TgrB1 and TgrC1, mediates the transition from unicellularity to multicellularity in the social amoeba Dictyostelium discoideum.},
  author={Shigenori Hirose and Balaji Srinivasan Santhanam and Mariko Katoh-Kurosawa and Gad Shaulsky and Adam Kuspa},
  journal={Development},
  year={2015},
  volume={142 20},
  pages={
          3561-70
        }
}
The social amoeba Dictyostelium discoideum integrates into a multicellular organism when individual starving cells aggregate and form a mound. The cells then integrate into defined tissues and develop into a fruiting body that consists of a stalk and spores. Aggregation is initially orchestrated by waves of extracellular cyclic adenosine monophosphate (cAMP), and previous theory suggested that cAMP and other field-wide diffusible signals mediate tissue integration and terminal differentiation… CONTINUE READING

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