Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues.

@article{Hornell1999AlloreactiveAS,
  title={Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues.},
  author={Tara M. C. Hornell and Joyce C. Solheim and Nancy B. Myers and William E. Gillanders and Ganesaratnam K. Balendiran and Ted H. Hansen and Janet M. Connolly},
  journal={Journal of immunology},
  year={1999},
  volume={163 6},
  pages={3217-25}
}
The molecular basis for the difference in the strength of T cell responses to self vs alloantigens is unknown, but may reflect how T cells are selected in the thymus. Because T cells with a high affinity for foreign as opposed to self MHC molecules are able to mature, it has been proposed that alloreactive T cells may be more strongly dependent upon interaction with MHC residues than are self-restricted T cells. This study was undertaken to rigorously address this hypothesis. Whereas other… CONTINUE READING

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