Alloreactive T cell recognition of the HLA-DR beta N-terminal polymorphic region.

@article{Ulrich1989AlloreactiveTC,
  title={Alloreactive T cell recognition of the HLA-DR beta N-terminal polymorphic region.},
  author={Robert G. Ulrich and M. Zouhair Atassi},
  journal={Immunology letters},
  year={1989},
  volume={21 4},
  pages={285-90}
}
T cell alloreactivity, originally discovered as a tissue transplantation effect, is believed to be a manifestation of the normal major histocompatibility complex (MHC) restriction of antigen presentation by accessory cells to T cells. The molecular features of the human class II-MHC proteins (HLA) which are recognized by alloreactive T cells are not at present understood, although they are clearly related to the polymorphic nature of the MHC proteins. Human CD4+ T cell clones were selected by… CONTINUE READING