Alloreactive Cytotoxic T Lymphocytes Generated in the Presence of Viral-Derived Peptides Show Exquisite Peptide and MHC Specificityl

Abstract

The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we have generated alloreactive CTL specific for exogenous, viral-derived peptide I igands. This approach… (More)

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