Alloreactive CD4 T cell activation in vivo: an autonomous function of the indirect pathway of alloantigen presentation.

@article{Reed2003AlloreactiveCT,
  title={Alloreactive CD4 T cell activation in vivo: an autonomous function of the indirect pathway of alloantigen presentation.},
  author={Amy Josephine Reed and Hooman Noorchashm and Susan Y. Rostami and Yasaman Zarrabi and Alison R. Perate and Arjun N Jeganathan and Andrew J. Caton and Ali Naji},
  journal={Journal of immunology},
  year={2003},
  volume={171 12},
  pages={
          6502-9
        }
}
Activation of alloreactive CD4 T cells occurs via the direct and indirect pathways of alloantigen presentation. A novel TCR/alloantigen transgenic system was designed that permitted in vivo visualization of CD4 T cell priming through these pathways. When both pathways of alloantigen presentation were intact, CD4 T cell activation in response to cardiac allografts was rapid and systemic by day 4 after transplantation, in contrast to that seen in response to skin allografts, which was delayed… CONTINUE READING
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