Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine.

@article{Sparrow2005AllopurinolSA,
  title={Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine.},
  author={M P Sparrow and Scott A Hande and Sonia Friedman and Wee Chian Lim and Sarathchandra I. Reddy and D Cao and S B Hanauer},
  journal={Alimentary pharmacology & therapeutics},
  year={2005},
  volume={22 5},
  pages={441-6}
}
BACKGROUND Many non-responders to azathioprine or mercaptopurine (6-mercaptopurine) have high normal thiopurine methyltransferase activity and preferentially metabolize mercaptopurine to produce 6-methylmercaptopurine instead of the active 6-tioguanine (6-tioguanine) metabolites. AIM To describe the use of allopurinol in mercaptopurine/azathioprine non… CONTINUE READING