Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting.

@article{Coghlan1994AllopurinolPI,
  title={Allopurinol pretreatment improves postoperative recovery and reduces lipid peroxidation in patients undergoing coronary artery bypass grafting.},
  author={J Gerrard Coghlan and William D Flitter and S M Clutton and Rajendran Panda and Robert Daly and Gordon Wright and Charles D J Ilsley and Trevor F. Slater},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1994},
  volume={107 1},
  pages={248-56}
}
In this prospective, randomized, double-blind, placebo-controlled study, the clinical, biochemical, and hemodynamic effects of xanthine oxidase inhibition in patients undergoing coronary artery bypass grafting were assessed. Allopurinol pretreatment significantly reduced the use of inotropic support after the operation (5 of 25 patients versus 13 of 25 patients, p < 0.01) and increased the rate of peripheral warming (11.4 +/- 0.85 hours versus 14.4 +/- 1 hours, p < 0.02). Twenty patients (9 in… CONTINUE READING

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