Allopurinol pharmacogenetics: assessment of potential clinical usefulness.

  title={Allopurinol pharmacogenetics: assessment of potential clinical usefulness.},
  author={Issam Zineh and Padmaja Mummaneni and Jenna Lyndly and Shashi Amur and Lois A La Grenade and Stephen H Chang and Hobart L Rogers and Michael A. Pacanowski},
  volume={12 12},
Use of pharmacogenetics to inform treatment decisions remains a priority for clinicians, patients and public health agencies. We previously developed a framework for systematically assessing whether pharmacogenetic test information would likely bring value to clinical decision-making and enjoy practical uptake. We applied this tool to allopurinol to determine potential usefulness of HLA genetic information in assessing risk for allopurinol-induced severe cutaneous adverse reactions. We… CONTINUE READING

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