Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy.

@article{Cappola2001AllopurinolIM,
  title={Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy.},
  author={Thomas P. Cappola and David A. Kass and G S Nelson and R D Berger and Gisele O. Rosas and Zoulficar A. Kobeissi and Eduardo Marb{\'a}n and Joshua M Hare},
  journal={Circulation},
  year={2001},
  volume={104 20},
  pages={2407-11}
}
BACKGROUND Dilated cardiomyopathy is characterized by an imbalance between left ventricular performance and myocardial energy consumption. Experimental models suggest that oxidative stress resulting from increased xanthine oxidase (XO) activity contributes to this imbalance. Accordingly, we hypothesized that XO inhibition with intracoronary allopurinol improves left ventricular efficiency in patients with idiopathic dilated cardiomyopathy. METHODS AND RESULTS Patients (n=9; ejection fraction… CONTINUE READING