Allopurinol for heart failure: novel mechanisms.

  title={Allopurinol for heart failure: novel mechanisms.},
  author={Lionel Henry Opie},
  journal={Journal of the American College of Cardiology},
  volume={59 9},
Oh, for oxygen is the cry that we could imagine coming from the famished cardiomyocytes in heart failure (HF). But how can energy in the form of adenosine triphosphate (ATP) be conserved? The principles are much like those of the economy: either cut the demand for dollars or increase the supply or do both. A simple way of energy conservation is to rest the heart, for example, by decreasing the heart rate by beta-blockade or ivabridine. Equally simple is reduction of the afterload by inhibition… CONTINUE READING

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