Allopurinol augmentation in the outpatient treatment of bipolar mania: a pilot study.

@article{Fan2012AllopurinolAI,
  title={Allopurinol augmentation in the outpatient treatment of bipolar mania: a pilot study.},
  author={Alexander H Fan and Andrew Berg and Catherine S Bresee and Lisa H Glassman and Mark Hyman Rapaport},
  journal={Bipolar disorders},
  year={2012},
  volume={14 2},
  pages={
          206-10
        }
}
BACKGROUND Allopurinol promotes the salvage of purines, possibly increasing endogenous adenosine levels. Recent studies suggest that adenosine has neuroprotective and inhibitory effects. Two previous inpatient trials demonstrated that allopurinol has anti-manic activity. Our objective was to test allopurinol as an adjunct to standard medications in bipolar disorder manic outpatients. METHODS In this double-blind, placebo-controlled trial, 27 subjects who met DSM-IV criteria for bipolar… CONTINUE READING
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