Allopurinol and Cardiovascular Outcomes in Adults With Hypertension.

  title={Allopurinol and Cardiovascular Outcomes in Adults With Hypertension.},
  author={Rachael L Macisaac and Janek Salatzki and Peter Higgins and Matthew R. Walters and Sandosh Padmanabhan and Anna F. Dominiczak and Rhian M Touyz and Jesse Dawson},
  volume={67 3},
Allopurinol lowers blood pressure in adolescents and has other vasoprotective effects. Whether similar benefits occur in older individuals remains unclear. We hypothesized that allopurinol is associated with improved cardiovascular outcomes in older adults with hypertension. Data from the United Kingdom Clinical Research Practice Datalink were used. Multivariate Cox-proportional hazard models were applied to estimate hazard ratios for stroke and cardiac events (defined as myocardial infarction… CONTINUE READING