Allopurinol administered prior to hepatic ischaemia in the rat prevents chemiluminescence following restoration of circulation.

  • P J Cohen
  • Published 1992 in
    Canadian journal of anaesthesia = Journal…
Oxygen-derived free radicals produced during reperfusion may be responsible for the disturbed pathology which follows prolonged ischaemia. Measurement of hepatic chemiluminescence (low level light emission resulting from the energy released during chemical reactions of free radicals) allowed determination of whether allopurinol could prevent formation of… (More)