Allopurinol Dosing in Renal Impairment: Walking the Tightrope Between Adequate Urate Lowering and Adverse Events

@article{Dalbeth2007AllopurinolDI,
  title={Allopurinol Dosing in Renal Impairment: Walking the Tightrope Between Adequate Urate Lowering and Adverse Events},
  author={Nicola Dalbeth and Lisa K. Stamp},
  journal={Seminars in Dialysis},
  year={2007},
  volume={20}
}
Allopurinol is the mainstay of urate‐lowering therapy for patients with gout and impaired renal function. Although rare, a life‐threatening hypersensitivity syndrome may occur with this drug. The risk of this allopurinol hypersensitivity syndrome (AHS) is increased in renal impairment. The recognition that AHS may be because of delayed‐type hypersensitivity to oxypurinol, the main metabolite of allopurinol, and that oxypurinol concentrations are frequently elevated in patients with renal… 
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