Allopurinol: Alteration in Pyrimidine Metabolism in Man

@article{Kelley1970AllopurinolAI,
  title={Allopurinol: Alteration in Pyrimidine Metabolism in Man},
  author={W. N. Kelley and T. Beardmore},
  journal={Science},
  year={1970},
  volume={169},
  pages={388 - 390}
}
In addition to its well-established inhibitory effect on uric acid synthesis, allopurinol appears to alter substantially pyrimidine metabolism, as evidenced by a striking increase in the urinary excretion of orotidine and orotic acid. Allopurinol ribonucleotide and xanthosine 5'-monophosphate are potent inhibitors of human erythrocyte orotidylic decarboxylase and provide a possible mechanism for this effect. 
POTENTIATION OF AN EFFECT OF ALLOPURINOL ON PYRIMIDINE METABOLISM BY CHLOROTHIAZIDE IN MAN
Effect of allopurinol on pyrimidine metabolism in human white blood cells. Role of the salvage pathway.
Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis.
The molecular basis for the effects of allopurinol on pyrimidine metabolism.
Depletion of erythrocyte phosphoribosylpyrophosphate in man.
Pyrimidine metabolism in man.
  • L. Smith
  • Biology, Medicine
  • The New England journal of medicine
  • 1973
The effect of different purines and pyrimidines on human pyrimidine biosynthesis.
ALLOPURINOL AND OXIPURINOL: ALTERATION OF PURINE AND PYRIMIDINE METABOLISM IN CELL CULTURE
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