Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.

@article{Hu2012AllopurinolQA,
  title={Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats.},
  author={Qing-hua Hu and Xian Zhang and Ying Pan and Yu-cheng Li and Ling-dong Kong},
  journal={Biochemical pharmacology},
  year={2012},
  volume={84 1},
  pages={
          113-25
        }
}
The NOD-like receptor 3 (NLRP3) inflammasome-mediated inflammation is recently recognized in the development of renal injury. However, the mechanisms of the inflammasome-mediated inflammation and lipid accumulation in renal injury and the actions of lowing urate agents remain unclear. The present study used fructose to induce hyperuricemia and dyslipidemia, which caused renal NLRP3 inflammasome activation characterized by over-expression of the NLRP3, apoptosis-associated speck-like protein… CONTINUE READING

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