Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann‐Pick C mice

@article{Ahmad2005AllopregnanoloneTB,
  title={Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann‐Pick C mice},
  author={Iram Ahmad and Silvia Lope-Piedrafita and Xiaoning Bi and Chad Hicks and Yueqin Yao and Clara Yu and Elizabeth Chaitkin and Christine M. Howison and Lyndon Weberg and Theodore P. Trouard and Robert P. Erickson},
  journal={Journal of Neuroscience Research},
  year={2005},
  volume={82}
}
Niemann‐Pick C disease (NPC) is an irreversible neurodegenerative disorder without current treatment. It is thought to result from deficient intracellular cholesterol and/or ganglioside trafficking. We have investigated the effects of allopregnanolone treatments on survival, weight loss, motor function, magnetic resonance imaging (MRI), and neuropathology in the mouse model of NPC (Npc1–/– mice). We confirmed previous results showing that a single injection of 250 μg of allopregnanolone on… 

MRI detects therapeutic effects in weanling Niemann‐Pick type C mice

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Therapeutic potential of cyclodextrins in the treatment of Niemann–Pick type C disease

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