Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.

@article{Ahmad2005AllopregnanoloneTB,
  title={Allopregnanolone treatment, both as a single injection or repetitively, delays demyelination and enhances survival of Niemann-Pick C mice.},
  author={Iram Ahmad and Silvia Lope-Piedrafita and Xiaoning Bi and Chad M Hicks and Yueqin Yao and Clara Yu and Elizabeth Chaitkin and Christine M Howison and Lyndon Weberg and Theodore P. Trouard and Robert P. Erickson},
  journal={Journal of neuroscience research},
  year={2005},
  volume={82 6},
  pages={811-21}
}
Niemann-Pick C disease (NPC) is an irreversible neurodegenerative disorder without current treatment. It is thought to result from deficient intracellular cholesterol and/or ganglioside trafficking. We have investigated the effects of allopregnanolone treatments on survival, weight loss, motor function, magnetic resonance imaging (MRI), and neuropathology in the mouse model of NPC (Npc1(-/-) mice). We confirmed previous results showing that a single injection of 250 microg of allopregnanolone… CONTINUE READING